Alfredo Brillembourg was born in New York City in 1961 and is a graduate of Columbia University, B.A. '84, M.Arch. '86, where he studied under Romaldo Giurgula, Tod Williams, and Henry Smith-Miller. On returning to Venezuela he validated his professional degree at the Universidad Central de Venezuela and opened Alfredo Brillembourg & Asociados in Caracas. In 1993 he founded the Caracas Urban Think Tank with fellow architect Andrew MacNair. In 1996 he, Antonio Valenilla and Ricardo Guinand formed BVG Arquitectos + Ingenieros, also in Caracas.
Alfredo Brillembourg has taught architectural design at Universidad José María Vargas, Universidad Simón Bolívar, and Universidad Central de Venezuela, has lectured at various international symposia, and has sat on design review juries at Cooper Union and Columbia University. In 1994 he collaborated on publications on the work of renowned Venezuelan architects Jimmy Alcock and Alejandro Pietri.